➊ The Birthmark Theme
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The Birthmark by Nathaniel Hawthorne
Everything you need for every book you read. The way the content is organized and presented is seamlessly smooth, innovative, and comprehensive. LitCharts assigns a color and icon to each theme in Lord of the Flies , which you can use to track the themes throughout the work. Back at the beach, Ralph blows the conch to call another meeting. Ralph announces that they're on an uninhabited island. Jack interrupts to say that they still need an army in order to hunt pigs. Jack needs to be in control: he interrupts Ralph to demonstrate his importance. Active Themes. Human Nature. Ralph says that without adults , they'll have to take care of themselves. He makes a rule that whoever holds the conch at meetings gets to speak.
The boys' first law is focused on the conch and made by Ralph. Jack , excited, shouts out that they can make more rules and punish whoever breaks them. Jack likes law only because he likes to punish. Savagery and the "Beast". Piggy takes the conch and says no one knows they're on the island. Ralph agrees, but describes the island as a good place where they'll have fun even if they have to stay for a long time. Only Piggy sees the big picture. Ralph and the other boys focus on short term pleasure and fun.
A nervous little boy with a birthmark that covers half his face steps forward. After some prodding, the boy whispers to Piggy , and Piggy tells everyone what the boy said. He saw a " beastie ," a "snake-thing," the previous night in the woods. Ralph and the older boys dismiss this "beastie" as just a nightmare, but the younger boys seem scared. Jack grabs the conch and says there's no snake-thing. If there is, he adds, his hunters will find and kill it.
Ralph also says there's no snake-thing. The beast's first appearance. Complications may include esophageal narrowing , squamous cell skin cancer , and the need for amputations. EB is due to a mutation in at least one of 16 different genes. Some types are autosomal dominant while others are autosomal recessive. The diagnosis is suspected based on symptoms and confirmed by skin biopsy or genetic testing. There is no cure for the condition. Management involves wound care , pain control, controlling infections , nutritional support, and prevention and treatment of complications.
Epidermolysis bullosa refers to a group of disorders that involve the formation of blisters following trivial trauma. Over mutations have been identified in this condition. It typically affects the hands and feet, and is typically inherited in an autosomal dominant manner, affecting the keratin genes KRT5 and KRT Therefore, there is a failure in keratinisation, which affects the integrity and the ability of the skin to resist mechanical stresses.
Junctional epidermolysis bullosa JEB is an inherited disease affecting laminin and collagen. It also presents with blisters at the site of friction, especially on the hands and feet, and has variants that can occur in children and adults. Less than one person per million people is estimated to have this form of EB. Dystrophic epidermolysis bullosa DEB is an inherited variant affecting the skin and other organs. Epidermis bullosa pruriginosa and albopapuloid epidermolysis bullosa Pasini's disease are rare subtypes of this disease.
The human skin consists of two layers: an outermost layer called the epidermis and a layer underneath called the dermis. In individuals with healthy skin, there are protein anchors between these two layers that prevent them from moving independently from one another shearing. In people born with EB, the two skin layers lack the protein anchors that hold them together, resulting in extremely fragile skin—even minor mechanical friction like rubbing or pressure or trauma will separate the layers of the skin and form blisters and painful sores. Sufferers of EB have compared the sores with third-degree burns.
Furthermore, as a complication of the chronic skin damage, people suffering from EB have an increased risk of malignancies cancers of the skin. EB can be diagnosed either by a skin punch biopsy at the edge of a wound with immunofluorescent mapping, or via blood sample and genetic testing. Recent research has focused on changing the mixture of keratins produced in the skin. There are 54 known keratin genes—of which 28 belong to the type I intermediate filament genes and 26 to type II—which work as heterodimers.
If the balance of production could be shifted away from the mutated, dysfunctional keratin gene toward an intact keratin gene, symptoms could be reduced. As of clinical research at the University of Minnesota has explored allogeneic bone marrow transplantation for RD and junctional EB, treating a 2-year-old child who is one of 2 brothers with EB. A second transplant has also been performed on the child's older brother, and a third transplant is scheduled for a California baby. A clinical trial is planned for 30 subjects. Rather, it is speculated that cross-correction from tissue-resident graft-derived immune cells contributes to the observed clinical benefit. A pilot study performed in suggests that systemic granulocyte-colony stimulating factor G-CSF may promote increased wound healing in people with dystrophic EB.
It has also been designed to evaluate the response to new therapies for the treatment of EB. It was presented at the International Investigative Dermatology congress in Edinburgh in and a paper-based version was published in the Journal of the American Academy of Dermatology in The first two types tended to die in infancy and the last in early adulthood.
An estimated 20 per million live births are diagnosed with EB,  and 9 per million people in the general population have the condition. The disorder occurs in every racial and ethnic group and affects both sexes. The EBRP hosts several annual fundraising events. Ortiz's daughter, Lismercedes, was born with EB. Other terms used to describe those affected include "butterfly children" as the skin is fragile as a butterfly's wings,  "cotton wool babies",   or "crystal skin children". From Wikipedia, the free encyclopedia. Parts of this article those related to treatment with genetically modified skin grafts need to be updated. Please help update this article to reflect recent events or newly available information.
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